15: The best number of eggs for IVF success

Agence France-Presse
First Posted 09:17:00 05/11/2011

PARIS—Retrieving about 15 eggs from a woman's ovaries in a single cycle gives the best chance of having a baby through in-vitro fertilization (IVF), researchers reported on Wednesday.

Investigators led by Arri Coomarasamy of the University of Birmingham in central England looked at data from more than 400,000 IVF cycles in Britain between 1991 and 2008.

Harvesting around 15 eggs in one go gave the best statistical chance of a live birth, they found.

This finding is in line with middle-range doses of powerful hormones to stimulate egg production, they found.

The chances of a baby level off between 15 and 20 eggs and then steadily decline beyond 20 eggs.

The success rate for 15 eggs in 2006-2007 was 40 percent among women aged 18-34, 36 percent for those aged 35-37, 27 percent for those aged 38-39 and 16 percent for women aged 40 or more.

The findings should be a useful tool for fertility doctors who want to make IVF as efficient as possible, avoid wasting precious eggs and limit the risk of dangerously overstimulating the ovaries, say the authors.

Previous research has looked at the link between egg numbers and pregnancy rates, but this is the first to explore the outcome in terms of live births.

The study appears in a European journal, Human Reproduction.

"Live birth" was defined as an event in which at least one baby was born alive.

IVF treatments entail taking eggs and fertilizing them in a lab dish with sperm. Several early-stage embryos are then implanted in the uterus in the hope that one will result in a live birth, although multiple births sometimes result.

Embryos that are not immediately implanted are usually frozen, so that they can be thawed for future IVF attempts.

The data used in the study did not distinguish between live births that resulted from fresh or thawed embryos.

Tiger Woods back on course after injury scare

PONTE VEDRA BEACH—Tiger Woods, coming back this week at the Players Championship after a knee injury, said Tuesday that his ongoing 18-month victory drought has lasted longer than he expected.

Woods practiced over the front nine at the TPC Sawgrass layout and will tee off for his first competitive round since last month's Masters on Thursday morning at 8:08 alongside Germany's Martin Kaymer and American Matt Kuchar.

World No. 8 Woods, a 14-time major champion chasing the all-time record of 18 majors won by Jack Nicklaus, has not won since his infamous sex scandal was revealed in November of 2009.

"There were some down times," Woods said. "This one has lasted longer than I would have expected. But you keep on playing, keep working hard and get through it."

Woods suffered a setback in that cause when he suffered a sprained left knee ligament and strained left Achilles tendon while playing at the Masters last month. He shared fourth for the second year in a row, matching his best showing since the sex scandal erupted.

"I had to power through and we had to shut it down for a little bit and take care of it," Woods said. "Nothing major. Hopefully it won't (swell this week) but if it does that's why I have ice and soft tissue work."

Woods, who withdrew from last year's Players Championship with a neck injury, has not won the Players title since 2001 but wanted to play the event after missing last week's tournament at Charlotte, a course he enjoys.

"I need some playing time. I really want to get out there and compete," said Woods, who decided to play only after seeing how his knee progressed after treatment.

"The strength of it, the swelling and pain," Woods said. "I had a slight injury, take some time off, listen to the docs and do the proper rehab. We'll see how this week progresses. If it flares up, it flares up. Hopefully it doesn't."

Woods has his next chance to end the longest major title drought of his career at next month's US Open at Congressional Country Club near Washington, a course where he won in 2009 at a PGA event in which he served as host.

Woods said the gap between winning his first major crown at the 1997 Masters and his next two years later at the PGA Championship helps him cope with his current struggles as he works to change his swing, something he did then as well.

"If I had never gone through '97 to '99, then this period would have been just brutal," Woods said.

Woods, who stands 69th on the US PGA money list, has slid from the world No. 1 ranking he held last October.

US standout Bubba Watson had said Woods appeared to be "going in the wrong direction" and said Tuesday that while he had been welcomed by members of Woods' entourage, he had yet to hear from "the boss".

Woods said of Watson's analysis, "That was interesting", and added, "We'll talk."

On the eve of the funeral of Seve Ballesteros, Woods voiced his admiration for the Spanish golf legend and five-time major winner who died on Saturday at age 54 due to complications related to brain tumor.

"Just the way he played, it was fun to watch," Woods said. "He didn't drive it all that straight but when he did he was virtually unbeatable.

"The way he played, chipping in and holing out from everywhere, I would have loved to have played in that time, just to see that and compete against him.